Endocrine Abstracts

Introduction:Adrenocorticotropic hormone (ACTH) deficiency can occur either due to decreased or absent production of the hormone by the pituitary gland. A decline in the production of ACTH can result in adrenal insufficiency. The exact etiology of ACTH deficiency is unknown. A defect in the hypothalamus or pituitary gland may be the cause. This can also be congenital involving mutations of the TBX19 gene (also referred to as TPIT) on the long arm of chro...